Omega-3 Essential Fatty Acids: The Role of these Healthy Fats in Inflammation and Health

omega-3

Fish and fish oils—or krill oils—are high in the type of essential fatty acid known as the omega-3 fats. We need fat to be healthy—even though the word “fat” has gotten a bad name—especially recently—but there ARE such things as healthy fats! One of the main reasons omega-3 fats are so important in human health is because they function as anti-inflammatory substances.

Let’s examine the omega-3 fats and see why they are considered so important. First, some of the basics.

Defining Terms and Basic Fat Facts

Defining Terms and Basic Fat Facts

First, let’s define some of the terms used:

  • Fats or fatty acids (FA) are long chains of carbon atoms linked to up to four hydrogen atoms and up to two oxygen atoms. The specific way the carbon, hydrogen, and oxygen atoms are linked defines fatty acids.
  • These FA can be saturated or unsaturated. Saturated fats mean that each carbon atom in the fat is attached to other carbon or hydrogen atoms with all 4 possible bonds made up of single bonds—in other words, the carbon atoms have the maximum number of bonds they can—they are saturated. Unsaturated fats have at least some carbon atoms that are double bonded to another carbon atom. Why is this important? Because UNsaturated fatty acids tend to be the healthier fats.
    • The unsaturated fats can be monounsaturated, meaning there is one (mono=1) double bond—they are then abbreviated as MonoUnsaturated Fatty Acids or MUFAs.
    • The unsaturated fats can also have more than one carbon with a double bond. These are the PolyUnsaturated Fatty Acids or PUFAs.
    • These MUFAs and PUFAs are thought to be the healthiest fats.
  • Hydrogenated fat is a phrase that refers to the chemical processing that adds extra hydrogen atoms to the FA, making them less healthy and fully saturated fats. The REALLY unhealthy trans fats are a result of this chemical processing.
  • One group of FA is called the essential fatty acids (or EFA) because humans cannot make them in adequate amounts for optimal health. The EFAs are the omega-3 FA and the omega-6 FA. The numbers 3 and 6 refer to the location of the double bonds.
    • There is really nothing unhealthy about omega-6 EFAs when eaten in moderation. They are just everywhere, so it is relatively easy to get enough omega-6 EFAs.
    • Omega-3 EFAs can be obtained through eating fish (tuna, mackerel, herring, salmon) and vegetables such as soybeans and soybean products (tofu, miso), walnuts, and flaxseed. The key thing to remember is the ratio between the omega-6 FA and the omega-3 FA.
    • We usually get enough omega-6 FA in foods. For optimal health, we want to increase the levels of the omega-3 FA and get the ratio (Omega-6: Omega-3) of these two types of fats as close as possible from 1:1 to about 4:1.
      • Ancient humans—who had a much lower rate of cancer and chronic diseases—are believed to have eaten roughly the same(1) amount of omega-3 and omega-6 fats—studies(2) indicate they ate about a 1:1 ratio., In some countries, people consume 20 times more Omega-6 than Omega-3! In those countries where the ratio of omega-6 to omega-3 is over 4:1, there is a corresponding(3) increase in

        chronic(4) disease.

According to the World Health Organization(5) and the Centers for Disease Control and Prevention, fats should make up anywhere between 20 and 35% of our calorie intake. Of this, roughly a third should come from saturated fats, another third from monounsaturated fats, and the rest from polyunsaturated fats.

What Do Omega-3 Essential Fatty Acids DO in the Body?

What Do Omega-3 Essential Fatty Acids DO in the Body?

The omega-3 essential fatty acids are PUFAs (as are the Omega-6 essential fatty acids). The omega-3 EFAs function(6) in helping to add structure to the cell membranes of all the cells in the body, provide a source of energy, and form a class of substances known as eicosanoids. The eicosanoids made from omega-3 EFAs funnel into producing anti-inflammatory substances and function in maintaining the cardiovascular, pulmonary, immune, and hormonal (endocrine) systems.

The three main omega-3 EFAs are:

  • alpha-linolenic acid (ALA)—derived from plant sources
  • eicosapentaenoic acid (EPA)—derived mainly from fish/seafood sources
  • docosahexaenoic acid (DHA)—derived mainly from fish/seafood sources

Clinical studies and meta-analyses(1) have shown that the omega-3 EFAs may help reduce the risk of heart disease, Alzheimer’s disease, cognitive loss, rheumatoid arthritis, and inflammation associated with several other diseases.1 Not all the studies have shown these effects, and studies continue. Use of omega-3 EFAs has been shown to be safe with minimal and usually mild adverse effects, which can include(1) an “unpleasant taste, bad breath, heartburn, nausea, gastrointestinal discomfort, diarrhea, headache, and odoriferous sweat”.

Omega-3 EFAs and Inflammation

Recent studies(7) have indicated that omega-3 EFAs can up-regulate genes specific to reducing the risk of atherosclerosis (an inflammatory condition) and decreasing LDL in the blood. Other studies have suggested that ingestion of omega-3 EFAs (up to 1-4 grams a day) can lower the biomarkers associated with both inflammation and oxidative stress(8).

Oxidative stress refers to the increase in free radicals within cells. This is often considered a prelude to systemic inflammation. Free radicals are naturally produced within cells and are normally “soaked up” by the body’s natural antioxidant system—which includes substances like glutathione, NAC and the antioxidant vitamins, Vitamins C, E, D, and A. However, if these are insufficient to soak up the free radicals, these highly reactive substances can damage cell organelles and cell structures. Eventually, these free radicals can also damage cellular proteins and DNA.

Omega-3 EFAs appear to benefit a number of conditions associated with inflammatory conditions, including heart disease,  Alzheimer’s Disease(9), depression(10), autoimmune disease(11), and overall human health(12).

Takeaways

All in all, omega-3 EFAs are important for cell structure and for providing the building blocks for anti-inflammatory eicosanoids, which help to control the normal inflammatory response. While there are some conflicting studies, the overall data indicate that taking 1-4 grams of omega-3 a day (or increasing the amounts of fatty fish in your diet) is a safe and effective way to reduce the risk of out-of-control inflammation and may decrease your risk for cardiovascular, autoimmune, and psychological disorders, including Alzheimer’s disease and cognitive disorders.

Resources:

  1. Wall R, Ross RP, Fitzgerald GF, Stanton C. Fatty acids from fish: the anti-inflammatory potential of long-chain omega-3 fatty acids. Nutr Rev. 2010 May;68(5):280-9. doi: 10.1111/j.1753-4887.2010.00287.x. PMID: 20500789. https://pubmed.ncbi.nlm.nih.gov/20500789/ 
  2. Innis SM, Novak EM, Keller BO. Long chain omega-3 fatty acids: micronutrients in disguise. Prostaglandins Leukot Essent Fatty Acids. 2013 Jan;88(1):91-5. doi: 10.1016/j.plefa.2012.05.007. Epub 2012 Jun 17. PMID: 22709913. https://pubmed.ncbi.nlm.nih.gov/22709913/ 
  3. O’Keefe JH Jr, Cordain L. Cardiovascular disease resulting from a diet and lifestyle at odds with our Paleolithic genome: how to become a 21st-century hunter-gatherer. Mayo Clin Proc. 2004 Jan;79(1):101-8. doi: 10.4065/79.1.101. PMID: 14708953. https://pubmed.ncbi.nlm.nih.gov/14708953/ 
  4. Benatar SR, Gill S, Bakker I. Global health and the global economic crisis. Am J Public Health. 2011 Apr;101(4):646-53. doi: 10.2105/AJPH.2009.188458. Epub 2011 Feb 17. PMID: 21330597; PMCID: PMC3052329. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052329/ 
  5. https://www.who.int/news-room/fact-sheets/detail/healthy-diet 
  6. https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/ 
  7. Heshmati J. Effect of omega-3 fatty acid supplementation on gene expression of inflammation, oxidative stress and cardiometabolic parameters: Systematic review and meta-analysis. Journal of Functional Foods. 2021 Oct 1;85:104619. https://www.sciencedirect.com/science/article/pii/S1756464621002681 
  8. Djuricic I, Calder PC. Beneficial outcomes of omega-6 and omega-3 polyunsaturated fatty acids on human health: an update for 2021. Nutrients. 2021 Jul 15;13(7):2421. https://www.mdpi.com/1189212 
  9. Mett J. The Impact of Medium Chain and Polyunsaturated ω-3-Fatty Acids on Amyloid-β Deposition, Oxidative Stress and Metabolic Dysfunction Associated with Alzheimer’s Disease. Antioxidants. 2021 Dec 14;10(12):1991. https://www.mdpi.com/1404970 
  10. Katrenčíková B, Vaváková M, Paduchová Z, Nagyová Z, Garaiova I, Muchová J, Ďuračková Z, Trebatická J. Oxidative stress markers and antioxidant enzymes in children and adolescents with depressive disorder and impact of omega-3 fatty acids in randomised clinical trial. Antioxidants. 2021 Aug 5;10(8):1256. https://www.mdpi.com/1218468 
  11. Ramessar N, Borad A, Schlesinger N. The effect of Omega-3 fatty acid supplementation in systemic lupus erythematosus patients: A systematic review. Lupus. 2022 Mar;31(3):287-96. https://journals.sagepub.com/doi/abs/10.1177/09612033211067985 
  12. Djuricic I, Calder PC. Beneficial outcomes of omega-6 and omega-3 polyunsaturated fatty acids on human health: an update for 2021. Nutrients. 2021 Jul 15;13(7):2421. https://www.mdpi.com/1189212